SLC26A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC26A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC26A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 26 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1836|1836]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50443|P50443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC26A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC26A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606718|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfate transporter. May play a role in endochondral bone formation. {ECO:0000269|PubMed:7923357}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfate transp|
|STAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|purine ribonucleoside bisphosphate biosynthetic process|
|3-phosphoadenosine 5-phosphosulfate biosynthetic process|
|oxalate transmembrane transporter activity|
|secondary active sulfate transmembrane transporter activity|
|oxalate transport|
|bicarbonate transmembrane transporter activity|
|sulfate transmembrane transporter activity|
|chloride transmembrane transporter activity|
|sulfate transmembrane transport|
|sulfate transport|
|anion:anion antiporter activity|
|microvillus membrane|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|purine ribonucleoside bisphosphate metabolic process|
|bicarbonate transport|
|sulfur compound transport|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|dicarboxylic acid transport|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|inorganic anion transport|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ossification|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|purine ribonucleotide metabolic process|
|apical plasma membrane|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|anion transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|organophosphate metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.82|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.76|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.73|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.77|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.79|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.96|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC26A2 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>