SLC27A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC27A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC27A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 27 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=376497|376497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PCB7|Q6PCB7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC27A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC27A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). {ECO:0000250, ECO:0000269|PubMed:12235169}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|medium-chain fatty acid transport|
|fatty acid transmembrane transporter activity|
|phosphatidylserine biosynthetic process|
|negative regulation of phospholipid biosynthetic process|
|cardiolipin biosynthetic process|
|adiponectin-activated signaling pathway|
|phosphatidylglycerol biosynthetic process|
|very long-chain fatty acid-CoA ligase activity|
|negative regulation of phospholipid metabolic process|
|long-chain fatty acid import into cell|
|lipid import into cell|
|positive regulation of heat generation|
|long-chain fatty acid transporter activity|
|positive regulation of triglyceride biosynthetic process|
|long-chain fatty acid-CoA ligase activity|
|regulation of heat generation|
|cardiolipin metabolic process|
|phosphatidylethanolamine biosynthetic process|
|regulation of triglyceride biosynthetic process|
|regulation of phospholipid biosynthetic process|
|positive regulation of triglyceride metabolic process|
|phosphatidylethanolamine metabolic process|
|phosphatidylglycerol metabolic process|
|phosphatidylserine metabolic process|
|phosphatidylcholine biosynthetic process|
|regulation of triglyceride metabolic process|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|cellular modified amino acid biosynthetic process|
|response to cold|
|negative regulation of lipid biosynthetic process|
|long-chain fatty acid transport|
|nucleotide binding|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|positive regulation of lipid biosynthetic process|
|negative regulation of lipid metabolic process|
|regulation of phospholipid metabolic process|
|phosphatidylinositol biosynthetic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid transport|
|positive regulation of lipid metabolic process|
|phosphatidylinositol metabolic process|
|hormone-mediated signaling pathway|
|response to temperature stimulus|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|response to insulin|
|phospholipid biosynthetic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|mitochondrial inner membrane|
|organic anion transport|
|response to peptide|
|regulation of protein serine/threonine kinase activity|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|anion transport|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to hormone|
|cellular lipid metabolic process|
|regulation of transferase activity|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|ion transport|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5786
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC27A1 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>