SLC27A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC27A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC27A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 27 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11001|11001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14975|O14975]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC27A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC27A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603247|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11980911}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pristanate-CoA ligase activity|
|phytanate-CoA ligase activity|
|methyl-branched fatty acid metabolic process|
|fatty acid transmembrane transporter activity|
|very long-chain fatty acid catabolic process|
|decanoate-CoA ligase activity|
|fatty acid alpha-oxidation|
|very long-chain fatty acid-CoA ligase activity|
|lipid import into cell|
|long-chain fatty acid import into cell|
|long-chain fatty acid transporter activity|
|long-chain fatty acid-CoA ligase activity|
|integral component of peroxisomal membrane|
|acyl-CoA ligase activity|
|bile acid biosynthetic process|
|very long-chain fatty acid metabolic process|
|bile acid metabolic process|
|peroxisomal membrane|
|fatty acid beta-oxidation|
|long-chain fatty acid transport|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|fatty acid transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|specific granule membrane|
|fatty acid catabolic process|
|integral component of endoplasmic reticulum membrane|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|steroid biosynthetic process|
|monocarboxylic acid transport|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|cellular lipid catabolic process|
|lipid modification|
|steroid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|endoplasmic reticulum lumen|
|organic acid biosynthetic process|
|lipid localization|
|fatty acid metabolic process|
|signaling receptor binding|
|enzyme binding|
|protein targeting|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|anion transport|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|ion transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7569
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC27A2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>