SLC30A7 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC30A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC30A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 30 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148867|148867]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEW0|Q8NEW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC30A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC30A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). {ECO:0000250, ECO:0000269|PubMed:15276077, ECO:0000269|PubMed:15994300}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation efflux|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of zinc ion|
|cation transmembrane transporter activity|
|sequestering of metal ion|
|zinc ion transport|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|transition metal ion homeostasis|
|vesicle|
|maintenance of location|
|cytoplasmic vesicle|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|Golgi apparatus|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.96|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.71|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.74|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.83|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.84|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.89|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.35|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC30A7 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>