SLC30A8 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC30A8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC30A8
  * **<color #00a2e8>Official Name</color>**: solute carrier family 30 member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=169026|169026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWU4|Q8IWU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC30A8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC30A8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation efflux|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of zinc ion|
|regulation of sequestering of zinc ion|
|sequestering of metal ion|
|zinc ion transmembrane transporter activity|
|zinc ion transmembrane transport|
|zinc ion transport|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|insulin secretion|
|transport vesicle membrane|
|response to zinc ion|
|peptide hormone secretion|
|positive regulation of insulin secretion|
|hormone secretion|
|hormone transport|
|secretory granule|
|positive regulation of peptide hormone secretion|
|secretory granule membrane|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|positive regulation of hormone secretion|
|transition metal ion homeostasis|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|protein secretion|
|establishment of protein localization to extracellular region|
|maintenance of location|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|regulation of insulin secretion|
|response to interferon-gamma|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to interleukin-1|
|regulation of peptide hormone secretion|
|cytoplasmic vesicle|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to metal ion|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to inorganic substance|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|zinc ion binding|
|protein homodimerization activity|
|cellular homeostasis|
|ion transmembrane transport|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11865
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC30A8 Expression in NALM6 Cells: -0.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>