SLC35B1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC35B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC35B1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 35 member B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10237|10237]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78383|P78383]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC35B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC35B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable sugar transporter. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EamA|
|UAA|
|TPT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-glucose transmembrane transporter activity|
|UDP-galactose transmembrane transport|
|UDP-galactose transmembrane transporter activity|
|UDP-glucose transmembrane transport|
|pyrimidine nucleotide-sugar transmembrane transport|
|nucleotide-sugar transmembrane transport|
|transmembrane transporter activity|
|integral component of Golgi membrane|
|carbohydrate derivative transport|
|carbohydrate transport|
|integral component of endoplasmic reticulum membrane|
|nucleobase-containing compound transport|
|anion transmembrane transport|
|organic anion transport|
|anion transport|
|intracellular membrane-bounded organelle|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.78|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.79|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.81|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.93|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.03|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.2|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.39|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.568|
|[[:human genes:h:hspd1|HSPD1]]|0.559|
|[[:human genes:r:rnmt|RNMT]]|0.527|
|[[:human genes:d:dpagt1|DPAGT1]]|0.519|
|[[:human genes:t:tti2|TTI2]]|0.516|
|[[:human genes:s:spcs3|SPCS3]]|0.513|
|[[:human genes:a:aars|AARS]]|0.508|
|[[:human genes:d:dnajc3|DNAJC3]]|0.496|
|[[:human genes:g:gmppb|GMPPB]]|0.496|
|[[:human genes:m:med16|MED16]]|0.492|
|[[:human genes:n:nars|NARS]]|0.489|
|[[:human genes:c:cct7|CCT7]]|0.489|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.481|
|[[:human genes:m:mars|MARS]]|0.47|
|[[:human genes:r:rpn1|RPN1]]|0.47|
|[[:human genes:t:triap1|TRIAP1]]|0.465|
|[[:human genes:r:rptor|RPTOR]]|0.464|
|[[:human genes:c:csnk2b|CSNK2B]]|0.462|
|[[:human genes:s:spcs2|SPCS2]]|0.462|
|[[:human genes:e:eif4e|EIF4E]]|0.457|
|[[:human genes:g:gfpt1|GFPT1]]|0.456|
|[[:human genes:c:ccdc101|CCDC101]]|0.454|
|[[:human genes:a:alg1|ALG1]]|0.448|
|[[:human genes:d:dad1|DAD1]]|0.447|
|[[:human genes:c:cbfb|CBFB]]|0.444|
|[[:human genes:s:smarcd1|SMARCD1]]|0.444|
|[[:human genes:m:meaf6|MEAF6]]|0.443|
|[[:human genes:b:bcl7a|BCL7A]]|0.439|
|[[:human genes:r:rtcb|RTCB]]|0.438|
|[[:human genes:s:srp72|SRP72]]|0.437|
|[[:human genes:t:telo2|TELO2]]|0.436|
|[[:human genes:d:dhdds|DHDDS]]|0.435|
|[[:human genes:d:derl2|DERL2]]|0.435|
|[[:human genes:u:uap1|UAP1]]|0.435|
|[[:human genes:a:alg5|ALG5]]|0.435|
|[[:human genes:m:med23|MED23]]|0.435|
|[[:human genes:m:manf|MANF]]|0.433|
|[[:human genes:a:atp5o|ATP5O]]|0.432|
|[[:human genes:g:gnb1l|GNB1L]]|0.431|
|[[:human genes:a:alg13|ALG13]]|0.429|
|[[:human genes:a:atp5j|ATP5J]]|0.428|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.428|
|[[:human genes:c:cars|CARS]]|0.426|
|[[:human genes:a:alg2|ALG2]]|0.425|
|[[:human genes:t:tti1|TTI1]]|0.423|
|[[:human genes:p:pelo|PELO]]|0.422|
|[[:human genes:m:mllt1|MLLT1]]|0.422|
|[[:human genes:p:pmm2|PMM2]]|0.42|
|[[:human genes:t:thg1l|THG1L]]|0.419|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.418|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.414|
|[[:human genes:v:vrk1|VRK1]]|0.412|
|[[:human genes:b:bap1|BAP1]]|0.409|
|[[:human genes:w:wars|WARS]]|0.409|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.409|
|[[:human genes:a:atp5b|ATP5B]]|0.407|
|[[:human genes:p:polr3h|POLR3H]]|0.407|
|[[:human genes:u:ube2g2|UBE2G2]]|0.407|
|[[:human genes:e:eny2|ENY2]]|0.407|
|[[:human genes:m:mad2l1|MAD2L1]]|0.406|
|[[:human genes:d:dhps|DHPS]]|0.406|
|[[:human genes:m:mtor|MTOR]]|0.405|
|[[:human genes:a:alg14|ALG14]]|0.404|
|[[:human genes:p:polr3b|POLR3B]]|0.403|
|[[:human genes:y:yars|YARS]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 87/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|4/26|
|breast|2/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|5/21|
|liver|5/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 294
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC35B1 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>