SLC38A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC38A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC38A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 38 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81539|81539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2H9|Q9H2H9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC38A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC38A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269|PubMed:10891391}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amino acid:sodium symporter activity|
|neutral amino acid transmembrane transporter activity|
|L-amino acid transmembrane transporter activity|
|neurotransmitter uptake|
|neutral amino acid transport|
|amino acid transmembrane transporter activity|
|L-alpha-amino acid transmembrane transport|
|L-amino acid transport|
|amino acid transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|sodium ion transport|
|neurotransmitter transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|regulation of neurotransmitter levels|
|monovalent inorganic cation transport|
|organic anion transport|
|anion transport|
|metal ion transport|
|import into cell|
|cation transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.2|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.02|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.7|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.454|
|[[:human genes:s:suv39h1|SUV39H1]]|0.411|
|[[:human genes:s:slc38a2|SLC38A2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4738
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC38A1 Expression in NALM6 Cells: 9.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>