SLC39A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC39A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC39A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 39 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283375|283375]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZMH5|Q6ZMH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC39A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC39A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zip|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to zinc ion starvation|
|cellular response to zinc ion starvation|
|G1 to G0 transition involved in cell differentiation|
|zinc ion import across plasma membrane|
|G1 to G0 transition|
|zinc ion transmembrane transporter activity|
|positive regulation of mRNA splicing, via spliceosome|
|zinc ion transmembrane transport|
|zinc ion transport|
|positive regulation of mRNA processing|
|cellular zinc ion homeostasis|
|positive regulation of RNA splicing|
|zinc ion homeostasis|
|neural precursor cell proliferation|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|positive regulation of mRNA metabolic process|
|BMP signaling pathway|
|import across plasma membrane|
|regulation of mRNA splicing, via spliceosome|
|cellular response to BMP stimulus|
|response to BMP|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|transition metal ion homeostasis|
|regulation of RNA splicing|
|regulation of mRNA processing|
|cellular response to starvation|
|response to starvation|
|basolateral plasma membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of mRNA metabolic process|
|cellular response to external stimulus|
|eye development|
|visual system development|
|sensory system development|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to growth factor|
|response to extracellular stimulus|
|sensory organ development|
|cell population proliferation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|molecular function|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|cell cycle process|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|cell cycle|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|homeostatic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC39A5 Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>