SLC4A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC4A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC4A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 4 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6522|6522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04920|P04920]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC4A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC4A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane anion exchange protein of wide distribution.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 3 cyto|
|HCO3 cotransp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anion transmembrane transporter activity|
|inorganic anion exchanger activity|
|anion:anion antiporter activity|
|bicarbonate transport|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|digestive tract development|
|monovalent inorganic cation homeostasis|
|digestive system development|
|inorganic anion transport|
|basolateral plasma membrane|
|anion transmembrane transport|
|apical plasma membrane|
|enzyme binding|
|focal adhesion|
|organic anion transport|
|spermatogenesis|
|male gamete generation|
|anion transport|
|cellular cation homeostasis|
|cellular ion homeostasis|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|cellular homeostasis|
|ion transmembrane transport|
|multi-organism reproductive process|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|homeostatic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.8|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7133
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC4A2 Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>