SLC7A6OS [The Human Chemical-Genetic Interaction Map Project]

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======= SLC7A6OS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A6OS
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 6 opposite strand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84138|84138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CW6|Q96CW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A6OS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A6OS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619192|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Directs RNA polymerase II nuclear import. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hematopoietic progenitor cell differentiation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.71|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.451|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.444|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.428|
|[[:human genes:p:pole|POLE]]|0.427|
|[[:human genes:c:cdca3|CDCA3]]|0.421|
|[[:human genes:s:ssh2|SSH2]]|0.418|
|[[:human genes:c:cdh24|CDH24]]|0.408|
|[[:human genes:b:bid|BID]]|0.407|
|[[:human genes:m:mbtd1|MBTD1]]|0.406|
|[[:human genes:c:c14orf93|C14orf93]]|0.403|
|[[:human genes:c:cope|COPE]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 656/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|22/26|
|breast|31/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|13/21|
|liver|18/20|
|lung|67/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A6OS Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>