SLMO2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLMO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRELID3B
  * **<color #00a2e8>Official Name</color>**: PRELI domain containing 3B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51012|51012]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3B1|Q9Y3B1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLMO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLMO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRELI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidic acid transfer activity|
|mitochondrial intermembrane space|
|phospholipid transport|
|organophosphate ester transport|
|lipid transport|
|lipid localization|
|organic anion transport|
|anion transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.71|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.74|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.76|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.84|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.86|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.07|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mfn1|MFN1]]|0.505|
|[[:human genes:h:hars|HARS]]|0.469|
|[[:human genes:v:vdac2|VDAC2]]|0.446|
|[[:human genes:o:opa1|OPA1]]|0.427|
|[[:human genes:c:crls1|CRLS1]]|0.426|
|[[:human genes:a:apaf1|APAF1]]|0.411|
|[[:human genes:t:triap1|TRIAP1]]|0.403|
|[[:human genes:r:romo1|ROMO1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 530/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|23/28|
|bone|15/26|
|breast|19/33|
|central nervous system|38/56|
|cervix|2/4|
|colorectal|13/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|15/21|
|liver|14/20|
|lung|56/75|
|lymphocyte|13/16|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|13/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|19/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1410
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLMO2 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>