SMAD7 [The Human Chemical-Genetic Interaction Map Project]

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======= SMAD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMAD7
  * **<color #00a2e8>Official Name</color>**: SMAD family member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4092|4092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15105|O15105]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMAD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMAD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602932|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:12023024, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:9892009}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MH2|
|MH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|
|regulation of ventricular cardiac muscle cell membrane depolarization|
|negative regulation of T cell cytokine production|
|negative regulation of T-helper 17 cell differentiation|
|negative regulation of transcription by competitive promoter binding|
|negative regulation of T-helper 17 type immune response|
|type I transforming growth factor beta receptor binding|
|I-SMAD binding|
|negative regulation of pathway-restricted SMAD protein phosphorylation|
|pathway-restricted SMAD protein phosphorylation|
|activin binding|
|response to laminar fluid shear stress|
|negative regulation of ubiquitin-protein transferase activity|
|negative regulation of T-helper cell differentiation|
|regulation of T-helper 17 cell differentiation|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of T cell mediated immunity|
|regulation of T-helper 17 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of alpha-beta T cell differentiation|
|cellular protein-containing complex localization|
|negative regulation of cytokine production involved in immune response|
|regulation of activin receptor signaling pathway|
|negative regulation of peptidyl-serine phosphorylation|
|negative regulation of epithelial to mesenchymal transition|
|catenin complex|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T cell cytokine production|
|response to fluid shear stress|
|regulation of T-helper cell differentiation|
|negative regulation of production of molecular mediator of immune response|
|adherens junction assembly|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|ventricular septum morphogenesis|
|negative regulation of T cell differentiation|
|regulation of peptidyl-threonine phosphorylation|
|regulation of membrane depolarization|
|negative regulation of adaptive immune response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|ventricular cardiac muscle tissue morphogenesis|
|negative regulation of BMP signaling pathway|
|negative regulation of leukocyte mediated immunity|
|regulation of ubiquitin-protein transferase activity|
|negative regulation of lymphocyte differentiation|
|ventricular cardiac muscle tissue development|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|artery morphogenesis|
|regulation of alpha-beta T cell differentiation|
|collagen binding|
|cardiac muscle tissue morphogenesis|
|regulation of T cell mediated immunity|
|ventricular septum development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of protein ubiquitination|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of cardiac muscle contraction|
|muscle tissue morphogenesis|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|beta-catenin binding|
|regulation of epithelial to mesenchymal transition|
|negative regulation of protein modification by small protein conjugation or removal|
|adherens junction organization|
|regulation of cytokine production involved in immune response|
|artery development|
|ureteric bud development|
|mesonephric epithelium development|
|muscle organ morphogenesis|
|mesonephric tubule development|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|regulation of striated muscle contraction|
|mesonephros development|
|regulation of alpha-beta T cell activation|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of leukocyte differentiation|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of proteasomal protein catabolic process|
|response to BMP|
|cellular response to BMP stimulus|
|cell-cell adherens junction|
|cardiac septum development|
|negative regulation of T cell activation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of protein ubiquitination|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of immune effector process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|fibrillar center|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of hemopoiesis|
|regulation of peptidyl-serine phosphorylation|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|positive regulation of cellular protein catabolic process|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of ubiquitin-dependent protein catabolic process|
|cellular response to transforming growth factor beta stimulus|
|regulation of adaptive immune response|
|regulation of muscle contraction|
|negative regulation of DNA-binding transcription factor activity|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|cell junction assembly|
|regulation of lymphocyte differentiation|
|cardiac chamber development|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|protein stabilization|
|regulation of proteasomal protein catabolic process|
|negative regulation of cell activation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of protein ubiquitination|
|transcription factor complex|
|regulation of leukocyte mediated immunity|
|cell junction organization|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|transcription regulatory region DNA binding|
|regulation of protein modification by small protein conjugation or removal|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of cellular protein catabolic process|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|protein-containing complex localization|
|negative regulation of cell migration|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|protein deubiquitination|
|striated muscle tissue development|
|renal system development|
|regulation of protein stability|
|regulation of blood circulation|
|ubiquitin protein ligase binding|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|muscle tissue development|
|protein modification by small protein removal|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|urogenital system development|
|negative regulation of locomotion|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of immune effector process|
|muscle structure development|
|blood vessel development|
|centrosome|
|cellular response to growth factor stimulus|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15477
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMAD7 Expression in NALM6 Cells: 2.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>