SMG1 [The Human Chemical-Genetic Interaction Map Project]

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======= SMG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMG1
  * **<color #00a2e8>Official Name</color>**: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23049|23049]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96Q15|Q96Q15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3 PI4 kinase|
|FATC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|telomeric DNA binding|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|regulation of telomere maintenance|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|phosphatidylinositol metabolic process|
|peptidyl-serine phosphorylation|
|nucleic acid transport|
|RNA transport|
|protein autophosphorylation|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|peptidyl-serine modification|
|lipid modification|
|mRNA catabolic process|
|RNA localization|
|regulation of response to DNA damage stimulus|
|protein kinase activity|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|glycerophospholipid metabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|protein serine/threonine kinase activity|
|nucleobase-containing compound catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|mRNA metabolic process|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|cellular macromolecule catabolic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|intracellular protein transport|
|macromolecule catabolic process|
|lipid metabolic process|
|phosphorylation|
|regulation of organelle organization|
|RNA binding|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.39|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.23|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.1|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.97|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.91|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.88|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.8|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.72|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.82|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.97|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.98|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.09|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.599|
|[[:human genes:s:smg7|SMG7]]|0.578|
|[[:human genes:p:psmd1|PSMD1]]|0.568|
|[[:human genes:p:psmd11|PSMD11]]|0.559|
|[[:human genes:a:atp13a1|ATP13A1]]|0.547|
|[[:human genes:p:psmc2|PSMC2]]|0.541|
|[[:human genes:p:psmc6|PSMC6]]|0.531|
|[[:human genes:u:upf1|UPF1]]|0.527|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.52|
|[[:human genes:p:pan3|PAN3]]|0.514|
|[[:human genes:p:pan2|PAN2]]|0.507|
|[[:human genes:o:ogfr|OGFR]]|0.503|
|[[:human genes:p:pola2|POLA2]]|0.497|
|[[:human genes:p:psmb4|PSMB4]]|0.496|
|[[:human genes:c:chd4|CHD4]]|0.494|
|[[:human genes:o:orc1|ORC1]]|0.492|
|[[:human genes:s:smg5|SMG5]]|0.492|
|[[:human genes:v:vasn|VASN]]|0.491|
|[[:human genes:r:ranbp2|RANBP2]]|0.489|
|[[:human genes:m:myo1h|MYO1H]]|0.488|
|[[:human genes:d:disp2|DISP2]]|0.48|
|[[:human genes:c:cbwd3|CBWD3]]|0.478|
|[[:human genes:a:ankle2|ANKLE2]]|0.477|
|[[:human genes:p:psmd14|PSMD14]]|0.477|
|[[:human genes:s:scaf1|SCAF1]]|0.477|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.476|
|[[:human genes:p:psmb1|PSMB1]]|0.469|
|[[:human genes:c:copa|COPA]]|0.467|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:d:ddtl|DDTL]]|0.462|
|[[:human genes:a:arcn1|ARCN1]]|0.462|
|[[:human genes:s:supt6h|SUPT6H]]|0.46|
|[[:human genes:z:znf830|ZNF830]]|0.459|
|[[:human genes:n:npipb5|NPIPB5]]|0.459|
|[[:human genes:p:psmd3|PSMD3]]|0.459|
|[[:human genes:c:cdca3|CDCA3]]|0.457|
|[[:human genes:s:ssh2|SSH2]]|0.454|
|[[:human genes:m:med14|MED14]]|0.454|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.452|
|[[:human genes:c:cbwd5|CBWD5]]|0.451|
|[[:human genes:k:kpnb1|KPNB1]]|0.45|
|[[:human genes:p:psmd13|PSMD13]]|0.45|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.449|
|[[:human genes:r:rrn3|RRN3]]|0.448|
|[[:human genes:z:znf106|ZNF106]]|0.448|
|[[:human genes:v:vps54|VPS54]]|0.447|
|[[:human genes:p:psma6|PSMA6]]|0.447|
|[[:human genes:t:traip|TRAIP]]|0.446|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.444|
|[[:human genes:c:copb1|COPB1]]|0.444|
|[[:human genes:m:mt1e|MT1E]]|0.443|
|[[:human genes:p:psmd6|PSMD6]]|0.442|
|[[:human genes:r:rad21|RAD21]]|0.442|
|[[:human genes:d:dnm2|DNM2]]|0.441|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.44|
|[[:human genes:c:cdc73|CDC73]]|0.438|
|[[:human genes:n:nol12|NOL12]]|0.438|
|[[:human genes:t:topbp1|TOPBP1]]|0.438|
|[[:human genes:r:riok2|RIOK2]]|0.437|
|[[:human genes:a:ankle1|ANKLE1]]|0.437|
|[[:human genes:n:nop16|NOP16]]|0.436|
|[[:human genes:n:nup153|NUP153]]|0.435|
|[[:human genes:d:dtl|DTL]]|0.435|
|[[:human genes:a:aatf|AATF]]|0.433|
|[[:human genes:t:terf2|TERF2]]|0.432|
|[[:human genes:p:prim1|PRIM1]]|0.432|
|[[:human genes:p:psmc1|PSMC1]]|0.432|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.431|
|[[:human genes:c:cnot1|CNOT1]]|0.43|
|[[:human genes:x:xab2|XAB2]]|0.43|
|[[:human genes:p:pcf11|PCF11]]|0.43|
|[[:human genes:s:smg6|SMG6]]|0.43|
|[[:human genes:d:ddx21|DDX21]]|0.428|
|[[:human genes:s:s1pr4|S1PR4]]|0.428|
|[[:human genes:n:nbpf10|NBPF10]]|0.427|
|[[:human genes:t:tceb3c|TCEB3C]]|0.426|
|[[:human genes:a:akirin2|AKIRIN2]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.425|
|[[:human genes:w:wdr75|WDR75]]|0.424|
|[[:human genes:t:tra2b|TRA2B]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.424|
|[[:human genes:p:psmd7|PSMD7]]|0.424|
|[[:human genes:e:exosc9|EXOSC9]]|0.422|
|[[:human genes:c:cbwd6|CBWD6]]|0.421|
|[[:human genes:t:taf1|TAF1]]|0.42|
|[[:human genes:f:fbxw9|FBXW9]]|0.42|
|[[:human genes:c:chchd3|CHCHD3]]|0.42|
|[[:human genes:i:ik|IK]]|0.42|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.419|
|[[:human genes:p:psmb2|PSMB2]]|0.419|
|[[:human genes:r:rps12|RPS12]]|0.419|
|[[:human genes:o:orc6|ORC6]]|0.417|
|[[:human genes:b:brd2|BRD2]]|0.417|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.417|
|[[:human genes:n:nbpf16|NBPF16]]|0.417|
|[[:human genes:n:narfl|NARFL]]|0.417|
|[[:human genes:t:tyms|TYMS]]|0.416|
|[[:human genes:n:nup160|NUP160]]|0.416|
|[[:human genes:l:lad1|LAD1]]|0.415|
|[[:human genes:t:twistnb|TWISTNB]]|0.415|
|[[:human genes:m:med17|MED17]]|0.414|
|[[:human genes:h:hap1|HAP1]]|0.414|
|[[:human genes:p:plcg2|PLCG2]]|0.413|
|[[:human genes:r:rnf121|RNF121]]|0.413|
|[[:human genes:m:myb|MYB]]|0.412|
|[[:human genes:p:polr2d|POLR2D]]|0.412|
|[[:human genes:k:kctd17|KCTD17]]|0.412|
|[[:human genes:p:polr2j3|POLR2J3]]|0.412|
|[[:human genes:c:cdc45|CDC45]]|0.411|
|[[:human genes:r:rpl30|RPL30]]|0.41|
|[[:human genes:n:ndc1|NDC1]]|0.409|
|[[:human genes:r:rps2|RPS2]]|0.409|
|[[:human genes:m:mbd6|MBD6]]|0.409|
|[[:human genes:p:pole|POLE]]|0.409|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.408|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.408|
|[[:human genes:m:mdm2|MDM2]]|0.408|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.408|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.408|
|[[:human genes:p:pigs|PIGS]]|0.407|
|[[:human genes:r:rnpc3|RNPC3]]|0.407|
|[[:human genes:x:xpo1|XPO1]]|0.407|
|[[:human genes:a:akap1|AKAP1]]|0.407|
|[[:human genes:r:rps14|RPS14]]|0.407|
|[[:human genes:r:rbm39|RBM39]]|0.407|
|[[:human genes:c:cope|COPE]]|0.406|
|[[:human genes:u:utp3|UTP3]]|0.406|
|[[:human genes:p:ppm1d|PPM1D]]|0.406|
|[[:human genes:t:terf1|TERF1]]|0.405|
|[[:human genes:f:fbxo5|FBXO5]]|0.405|
|[[:human genes:t:tspy1|TSPY1]]|0.405|
|[[:human genes:c:col2a1|COL2A1]]|0.405|
|[[:human genes:k:krt2|KRT2]]|0.404|
|[[:human genes:m:mbtd1|MBTD1]]|0.404|
|[[:human genes:r:rpl35|RPL35]]|0.404|
|[[:human genes:s:sel1l|SEL1L]]|0.403|
|[[:human genes:c:c14orf93|C14orf93]]|0.402|
|[[:human genes:s:ssrp1|SSRP1]]|0.401|
|[[:human genes:r:rpsa|RPSA]]|0.4|
|[[:human genes:c:cdt1|CDT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMG1 Expression in NALM6 Cells: 9.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>