SMOC2 [The Human Chemical-Genetic Interaction Map Project]

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======= SMOC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMOC2
  * **<color #00a2e8>Official Name</color>**: SPARC related modular calcium binding 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64094|64094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3U7|Q9H3U7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMOC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMOC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607223|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPARC Ca bdg|
|Kazal 2|
|Thyroglobulin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of vascular wound healing|
|positive regulation of vascular endothelial growth factor signaling pathway|
|regulation of vascular wound healing|
|positive regulation of fibroblast growth factor receptor signaling pathway|
|interstitial matrix|
|positive regulation of endothelial cell chemotaxis|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|regulation of endothelial cell chemotaxis|
|regulation of fibroblast growth factor receptor signaling pathway|
|cell periphery|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|positive regulation of DNA biosynthetic process|
|basement membrane|
|positive regulation of endothelial cell migration|
|regulation of DNA biosynthetic process|
|positive regulation of cell-substrate adhesion|
|positive regulation of chemotaxis|
|regulation of wound healing|
|positive regulation of epithelial cell migration|
|positive regulation of mitotic cell cycle|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|heparin binding|
|positive regulation of vasculature development|
|positive regulation of DNA metabolic process|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|extracellular structure organization|
|positive regulation of cell adhesion|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|regulation of mitotic cell cycle|
|regulation of cell adhesion|
|calcium ion binding|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|regulation of cell cycle|
|positive regulation of developmental process|
|regulation of response to stress|
|extracellular space|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14926
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMOC2 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>