SMU1 [The Human Chemical-Genetic Interaction Map Project]

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======= SMU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMU1
  * **<color #00a2e8>Official Name</color>**: SMU1 DNA replication regulator and spliceosomal factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55234|55234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2TAY7|Q2TAY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617811|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (PubMed:15878348). Required for normal accumulation of IK (PubMed:24945353). {ECO:0000250|UniProtKB:Q76B40, ECO:0000269|PubMed:15878348, ECO:0000269|PubMed:24945353, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type precatalytic spliceosome|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.41|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.05|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.91|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.84|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.77|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.7|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.75|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.13|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.19|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.2|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.26|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 879
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMU1 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>