SMURF1 [The Human Chemical-Genetic Interaction Map Project]

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======= SMURF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMURF1
  * **<color #00a2e8>Official Name</color>**: SMAD specific E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57154|57154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCE7|Q9HCE7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMURF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMURF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605568|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HECT|
|WW|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|engulfment of target by autophagosome|
|substrate localization to autophagosome|
|protein targeting to vacuole involved in autophagy|
|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|
|ubiquitin-dependent SMAD protein catabolic process|
|positive regulation of mitophagy in response to mitochondrial depolarization|
|positive regulation of mitophagy|
|I-SMAD binding|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|activin binding|
|regulation of mitophagy|
|response to mitochondrial depolarisation|
|positive regulation of autophagy of mitochondrion|
|ectoderm development|
|R-SMAD binding|
|positive regulation of dendrite extension|
|protein localization to cell surface|
|regulation of dendrite extension|
|receptor catabolic process|
|protein targeting to vacuole|
|regulation of autophagy of mitochondrion|
|establishment of protein localization to vacuole|
|negative regulation of BMP signaling pathway|
|autophagosome assembly|
|protein localization to vacuole|
|autophagosome organization|
|positive regulation of macroautophagy|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of ossification|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|positive regulation of ubiquitin-dependent protein catabolic process|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|phospholipid binding|
|receptor metabolic process|
|response to BMP|
|regulation of establishment of planar polarity|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of mitochondrion organization|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of autophagy|
|vacuole organization|
|non-canonical Wnt signaling pathway|
|positive regulation of cellular protein catabolic process|
|vacuolar transport|
|membrane invagination|
|negative regulation of cellular response to growth factor stimulus|
|protein export from nucleus|
|regulation of ubiquitin-dependent protein catabolic process|
|cellular response to transforming growth factor beta stimulus|
|nuclear export|
|macroautophagy|
|response to transforming growth factor beta|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|regulation of morphogenesis of an epithelium|
|protein localization to plasma membrane|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|protein localization to cell periphery|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|process utilizing autophagic mechanism|
|autophagy|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|axon|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of developmental growth|
|regulation of autophagy|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|protein targeting|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|positive regulation of neurogenesis|
|protein localization to membrane|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|regulation of growth|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|protein localization to organelle|
|organelle assembly|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|membrane organization|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMURF1 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>