SNRPB [The Human Chemical-Genetic Interaction Map Project]

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======= SNRPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPB
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein polypeptides B and B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6628|6628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14678|P14678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182282|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2 snRNP binding|
|histone pre-mRNA DCP binding|
|U1 snRNP binding|
|histone pre-mRNA 3end processing complex|
|U7 snRNP|
|U4 snRNP|
|methylosome|
|small nuclear ribonucleoprotein complex|
|U2-type prespliceosome|
|SMN-Sm protein complex|
|U5 snRNP|
|U1 snRNP|
|telomerase holoenzyme complex|
|telomerase RNA binding|
|U2 snRNP|
|U12-type spliceosomal complex|
|histone mRNA metabolic process|
|U2-type catalytic step 2 spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|termination of RNA polymerase II transcription|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|DNA-templated transcription, termination|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|import into nucleus|
|protein methylation|
|protein alkylation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|methylation|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|brain development|
|head development|
|cellular protein-containing complex assembly|
|RNA processing|
|central nervous system development|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.82|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.82|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.93|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.08|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.14|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.498|
|[[:human genes:s:sf3a2|SF3A2]]|0.456|
|[[:human genes:e:exosc6|EXOSC6]]|0.416|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.415|
|[[:human genes:p:psmb4|PSMB4]]|0.414|
|[[:human genes:p:prim1|PRIM1]]|0.409|
|[[:human genes:p:psmd3|PSMD3]]|0.408|
|[[:human genes:s:sf3b2|SF3B2]]|0.402|
|[[:human genes:r:rrp15|RRP15]]|0.401|
|[[:human genes:s:stil|STIL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPB Expression in NALM6 Cells: 8.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>