SNX10 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX10
  * **<color #00a2e8>Official Name</color>**: sorting nexin 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29887|29887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5X0|Q9Y5X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. {ECO:0000269|PubMed:17012226, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22499339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|apical cytoplasm|
|tooth eruption|
|extrinsic component of endosome membrane|
|gastric acid secretion|
|ruffle assembly|
|1-phosphatidylinositol binding|
|protein localization to microtubule organizing center|
|protein localization to centrosome|
|bone resorption|
|ruffle organization|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|osteoclast differentiation|
|bone remodeling|
|protein localization to cilium|
|bone mineralization|
|digestive system process|
|endosome organization|
|acid secretion|
|ATPase binding|
|secretory granule|
|biomineral tissue development|
|biomineralization|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|tissue remodeling|
|myeloid leukocyte differentiation|
|digestion|
|odontogenesis|
|tissue homeostasis|
|myeloid cell differentiation|
|ossification|
|vesicle organization|
|multicellular organismal homeostasis|
|leukocyte differentiation|
|anatomical structure homeostasis|
|cilium assembly|
|cilium organization|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|cell projection assembly|
|divalent inorganic cation homeostasis|
|centrosome|
|endocytosis|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|immune system development|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|organelle assembly|
|ion homeostasis|
|animal organ morphogenesis|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to cytokine|
|chemical homeostasis|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|tissue development|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.7|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.71|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.81|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.09|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.19|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.27|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX10 Expression in NALM6 Cells: -1.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>