SNX27 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX27
  * **<color #00a2e8>Official Name</color>**: sorting nexin 27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81609|81609]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L92|Q96L92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RA|
|PDZ|
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of natural killer cell polarity|
|establishment of lymphocyte polarity|
|WASH complex|
|retromer complex|
|retrograde transport, endosome to plasma membrane|
|immunological synapse|
|phosphatidylinositol-3-phosphate binding|
|endosome to lysosome transport|
|natural killer cell activation|
|phosphatidylinositol binding|
|vesicle-mediated transport to the plasma membrane|
|lysosomal transport|
|establishment of cell polarity|
|vacuolar transport|
|early endosome membrane|
|establishment or maintenance of cell polarity|
|endosomal transport|
|early endosome|
|endosome|
|lymphocyte activation|
|leukocyte activation|
|intracellular protein transport|
|cell activation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-4.81|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-3.1|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.29|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.21|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.96|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.94|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.8|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.79|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.78|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.78|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.77|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.72|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.71|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.73|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.76|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.77|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.78|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.85|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.92|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.51|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.78|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|3.55|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|5.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfkp|PFKP]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3665
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX27 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>