SOGA2 [The Human Chemical-Genetic Interaction Map Project]

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======= SOGA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTCL1
  * **<color #00a2e8>Official Name</color>**: microtubule crosslinking factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23255|23255]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4B5|Q9Y4B5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOGA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOGA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. {ECO:0000269|PubMed:23902687}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3166|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule motor activity|
|microtubule bundle|
|regulation of microtubule motor activity|
|apicolateral plasma membrane|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|lateral plasma membrane|
|regulation of protein targeting|
|microtubule bundle formation|
|positive regulation of protein localization to membrane|
|spindle pole|
|positive regulation of intracellular protein transport|
|midbody|
|regulation of protein localization to membrane|
|establishment or maintenance of cell polarity|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|microtubule binding|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|regulation of intracellular transport|
|cytoskeleton|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|regulation of cellular protein localization|
|microtubule-based process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|cytoskeleton organization|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|extracellular space|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.95|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8644
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOGA2 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>