SORBS1 [The Human Chemical-Genetic Interaction Map Project]

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======= SORBS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SORBS1
  * **<color #00a2e8>Official Name</color>**: sorbin and SH3 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10580|10580]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX66|Q9BX66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SORBS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SORBS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH3 1|
|Sorb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-substrate adherens junction|
|insulin receptor complex|
|zonula adherens|
|contractile actin filament bundle assembly|
|positive regulation of glycogen biosynthetic process|
|stress fiber assembly|
|positive regulation of glycogen metabolic process|
|positive regulation of insulin receptor signaling pathway|
|insulin receptor binding|
|positive regulation of cellular response to insulin stimulus|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|regulation of glycogen metabolic process|
|adherens junction assembly|
|positive regulation of glucose import|
|regulation of polysaccharide biosynthetic process|
|positive regulation of glucose metabolic process|
|cell-substrate junction assembly|
|regulation of polysaccharide metabolic process|
|positive regulation of glucose transmembrane transport|
|SH3/SH2 adaptor activity|
|positive regulation of protein localization to plasma membrane|
|regulation of glucose import|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of protein localization to cell periphery|
|actin filament bundle assembly|
|regulation of insulin receptor signaling pathway|
|actin filament bundle organization|
|stress fiber|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|cytoskeletal protein binding|
|positive regulation of lipid biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|adherens junction organization|
|insulin receptor signaling pathway|
|regulation of carbohydrate biosynthetic process|
|regulation of protein localization to plasma membrane|
|cell-cell adherens junction|
|nuclear matrix|
|regulation of glucose metabolic process|
|regulation of protein localization to cell periphery|
|actomyosin structure organization|
|positive regulation of protein localization to membrane|
|cell-matrix adhesion|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of lipid metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|cell junction assembly|
|cell-substrate adhesion|
|regulation of lipid biosynthetic process|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|cell junction organization|
|membrane raft|
|response to insulin|
|actin filament organization|
|muscle contraction|
|cellular response to peptide hormone stimulus|
|actin binding|
|muscle system process|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|response to peptide hormone|
|regulation of lipid metabolic process|
|focal adhesion|
|regulation of small molecule metabolic process|
|supramolecular fiber organization|
|response to peptide|
|centrosome|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|response to hormone|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|positive regulation of transport|
|response to organonitrogen compound|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cytoskeleton organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10295
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SORBS1 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>