SORBS2 [The Human Chemical-Genetic Interaction Map Project]

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======= SORBS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SORBS2
  * **<color #00a2e8>Official Name</color>**: sorbin and SH3 domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8470|8470]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94875|O94875]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SORBS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SORBS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616349|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|Sorb|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell growth involved in cardiac muscle cell development|
|physiological cardiac muscle hypertrophy|
|physiological muscle hypertrophy|
|cytoskeletal adaptor activity|
|cardiac muscle tissue growth|
|heart growth|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|muscle hypertrophy|
|structural constituent of muscle|
|cardiac muscle cell development|
|cardiac cell development|
|developmental cell growth|
|cardiac muscle cell differentiation|
|cell growth|
|organ growth|
|structural constituent of cytoskeleton|
|cardiocyte differentiation|
|Notch signaling pathway|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|cardiac muscle tissue development|
|lamellipodium|
|striated muscle cell differentiation|
|actin cytoskeleton|
|actin filament organization|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle tissue development|
|muscle system process|
|apical plasma membrane|
|developmental growth|
|growth|
|focal adhesion|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|actin filament-based process|
|perinuclear region of cytoplasm|
|circulatory system development|
|cytoskeleton organization|
|RNA binding|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.74|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.77|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.86|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SORBS2 Expression in NALM6 Cells: 1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>