SOX10 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX10
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6663|6663]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56693|P56693]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602229|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). {ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sox N|
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of mitochondrial outer membrane|
|cellular response to progesterone stimulus|
|regulation of Schwann cell proliferation|
|negative regulation of Schwann cell proliferation|
|lacrimal gland development|
|enteric nervous system development|
|negative regulation of glial cell proliferation|
|positive regulation of myelination|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|melanocyte differentiation|
|positive regulation of neuroblast proliferation|
|regulation of glial cell proliferation|
|pigment cell differentiation|
|regulation of neuroblast proliferation|
|positive regulation of stem cell proliferation|
|developmental pigmentation|
|negative regulation of gliogenesis|
|oligodendrocyte development|
|regulation of myelination|
|exocrine system development|
|response to progesterone|
|autonomic nervous system development|
|digestive tract morphogenesis|
|promoter-specific chromatin binding|
|positive regulation of neural precursor cell proliferation|
|neural crest cell migration|
|positive regulation of nervous system process|
|regulation of stem cell proliferation|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|peripheral nervous system development|
|transcription elongation from RNA polymerase II promoter|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|regulation of neural precursor cell proliferation|
|neural crest cell differentiation|
|DNA-templated transcription, elongation|
|cellular response to ketone|
|pigmentation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|chromatin|
|regulation of gliogenesis|
|digestive tract development|
|regulation of nervous system process|
|digestive system development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cell maturation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|glial cell differentiation|
|ameboidal-type cell migration|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to steroid hormone stimulus|
|response to ketone|
|negative regulation of Wnt signaling pathway|
|gliogenesis|
|mesenchyme development|
|developmental maturation|
|regulation of canonical Wnt signaling pathway|
|transcription coactivator activity|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|response to steroid hormone|
|transcription factor binding|
|negative regulation of cell development|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|developmental growth|
|growth|
|cellular response to drug|
|gland development|
|morphogenesis of an epithelium|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|tissue morphogenesis|
|regulation of system process|
|cellular response to hormone stimulus|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3522
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX10 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>