SOX17 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX17
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64321|64321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6I2|Q9H6I2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3547|
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification|
|cardiogenic plate morphogenesis|
|endodermal cell fate determination|
|endodermal digestive tract morphogenesis|
|inner cell mass cellular morphogenesis|
|regulation of cardiac cell fate specification|
|regulation of transcription involved in primary germ layer cell fate commitment|
|gall bladder development|
|cardiac cell fate determination|
|negative regulation of mesoderm formation|
|negative regulation of mesodermal cell fate specification|
|stem cell fate specification|
|endocardium formation|
|negative regulation of mesodermal cell differentiation|
|common bile duct development|
|negative regulation of Wnt signaling pathway involved in heart development|
|negative regulation of cell fate specification|
|regulation of Wnt signaling pathway involved in heart development|
|endocardium morphogenesis|
|endodermal cell fate specification|
|regulation of mesoderm formation|
|inner cell mass cell differentiation|
|regulation of mesodermal cell fate specification|
|regulation of mesodermal cell differentiation|
|negative regulation of gastrulation|
|cardiac endothelial cell differentiation|
|negative regulation of mesoderm development|
|endocardial cell differentiation|
|embryonic foregut morphogenesis|
|regulation of stem cell division|
|stem cell fate commitment|
|cardiac cell fate commitment|
|foregut morphogenesis|
|regulation of cell fate specification|
|rostrocaudal neural tube patterning|
|endodermal cell fate commitment|
|negative regulation of cell fate commitment|
|heart formation|
|endocardium development|
|cell migration involved in gastrulation|
|regulation of mesoderm development|
|regulation of transcription involved in cell fate commitment|
|mRNA transcription by RNA polymerase II|
|signal transduction involved in regulation of gene expression|
|nuclear transcription factor complex|
|positive regulation of skeletal muscle tissue development|
|mRNA transcription|
|negative regulation of embryonic development|
|regulation of cell fate commitment|
|cell fate commitment involved in formation of primary germ layer|
|neural tube patterning|
|animal organ formation|
|regulation of gastrulation|
|blastocyst formation|
|cell fate determination|
|endodermal cell differentiation|
|protein destabilization|
|endoderm formation|
|digestive tract morphogenesis|
|regulation of skeletal muscle tissue development|
|regulation of cardiocyte differentiation|
|heart looping|
|regulation of stem cell proliferation|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|vasculogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|outflow tract morphogenesis|
|endoderm development|
|embryonic heart tube development|
|endothelial cell differentiation|
|beta-catenin binding|
|cell fate specification|
|canonical Wnt signaling pathway|
|endothelium development|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|blastocyst development|
|formation of primary germ layer|
|cardiocyte differentiation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|regulation of embryonic development|
|hepaticobiliary system development|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|stem cell differentiation|
|gastrulation|
|neural tube development|
|regulation of cell division|
|ameboidal-type cell migration|
|negative regulation of canonical Wnt signaling pathway|
|protein stabilization|
|negative regulation of cell growth|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|negative regulation of growth|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|transcription coactivator activity|
|regulation of protein stability|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|angiogenesis|
|urogenital system development|
|transcription factor binding|
|regionalization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|regulation of protein catabolic process|
|blood vessel morphogenesis|
|regulation of cell growth|
|sequence-specific DNA binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|vasculature development|
|cardiovascular system development|
|heart development|
|spermatogenesis|
|cell morphogenesis involved in differentiation|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of growth|
|epithelial cell differentiation|
|gamete generation|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of catabolic process|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.84|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.78|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX17 Expression in NALM6 Cells: -3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>