SOX1 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX1
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6656|6656]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00570|O00570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602148|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|SOXp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell fate specification involved in pattern specification|
|ventral spinal cord interneuron specification|
|ventral spinal cord interneuron fate commitment|
|cell fate commitment involved in pattern specification|
|ventral spinal cord interneuron differentiation|
|spinal cord dorsal/ventral patterning|
|lens morphogenesis in camera-type eye|
|nuclear transcription factor complex|
|spinal cord patterning|
|forebrain neuron development|
|neuron fate specification|
|ventral spinal cord development|
|forebrain neuron differentiation|
|cell differentiation in spinal cord|
|neuron fate commitment|
|forebrain generation of neurons|
|lens development in camera-type eye|
|central nervous system neuron development|
|dorsal/ventral pattern formation|
|cell fate specification|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|spinal cord development|
|camera-type eye morphogenesis|
|neuron migration|
|eye morphogenesis|
|central nervous system neuron differentiation|
|cell fate commitment|
|sensory organ morphogenesis|
|camera-type eye development|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|DNA-binding transcription factor activity|
|chromatin organization|
|brain development|
|head development|
|neuron development|
|animal organ morphogenesis|
|cell migration|
|central nervous system development|
|cellular response to cytokine stimulus|
|neuron differentiation|
|chromosome organization|
|cell motility|
|localization of cell|
|response to cytokine|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|DNA binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18433
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX1 Expression in NALM6 Cells: -1.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>