SOX6 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX6
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55553|55553]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35712|P35712]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mesenchymal stem cell differentiation|
|oligodendrocyte cell fate commitment|
|glial cell fate specification|
|oligodendrocyte cell fate specification|
|regulation of mesenchymal stem cell differentiation|
|glial cell fate commitment|
|negative regulation of cardiac muscle cell differentiation|
|positive regulation of chondrocyte differentiation|
|negative regulation of cardiocyte differentiation|
|positive regulation of stem cell differentiation|
|negative regulation of cardiac muscle tissue development|
|erythrocyte development|
|positive regulation of cartilage development|
|regulation of cardiac muscle cell differentiation|
|negative regulation of striated muscle cell differentiation|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of cardiocyte differentiation|
|regulation of chondrocyte differentiation|
|negative regulation of muscle tissue development|
|astrocyte differentiation|
|negative regulation of muscle cell differentiation|
|myeloid cell development|
|oligodendrocyte differentiation|
|regulation of cartilage development|
|regulation of cardiac muscle tissue development|
|erythrocyte differentiation|
|cell fate specification|
|cardiac muscle cell differentiation|
|erythrocyte homeostasis|
|post-embryonic development|
|regulation of striated muscle cell differentiation|
|myeloid cell homeostasis|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|gene silencing|
|regulation of muscle cell differentiation|
|cellular response to transforming growth factor beta stimulus|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|glial cell differentiation|
|cartilage development|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|gliogenesis|
|myeloid cell differentiation|
|connective tissue development|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|cell fate commitment|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|in utero embryonic development|
|muscle structure development|
|protein heterodimerization activity|
|skeletal system development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|response to growth factor|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX6 Expression in NALM6 Cells: 2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>