SPACA3 [The Human Chemical-Genetic Interaction Map Project]

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======= SPACA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPACA3
  * **<color #00a2e8>Official Name</color>**: sperm acrosome associated 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124912|124912]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXA5|Q8IXA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPACA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPACA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612749|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269|PubMed:12606493}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lys|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acrosomal matrix|
|lysozyme activity|
|monocyte activation|
|fusion of sperm to egg plasma membrane involved in single fertilization|
|acrosomal membrane|
|plasma membrane fusion|
|positive regulation of macrophage activation|
|sperm-egg recognition|
|regulation of macrophage activation|
|positive regulation of phagocytosis|
|cell-cell recognition|
|defense response to Gram-negative bacterium|
|secretory granule|
|defense response to Gram-positive bacterium|
|regulation of phagocytosis|
|membrane fusion|
|single fertilization|
|fertilization|
|cell recognition|
|defense response to bacterium|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|response to bacterium|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|leukocyte activation|
|defense response to other organism|
|positive regulation of transport|
|multi-organism reproductive process|
|cell activation|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|regulation of immune system process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPACA3 Expression in NALM6 Cells: -2.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>