SPCS1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPCS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPCS1
  * **<color #00a2e8>Official Name</color>**: signal peptidase complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28972|28972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6A9|Q9Y6A9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPCS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPCS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPC12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal peptidase complex|
|signal peptide processing|
|peptidase activity|
|integral component of endoplasmic reticulum membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein processing|
|protein maturation|
|protein targeting|
|establishment of protein localization to organelle|
|peptide metabolic process|
|protein localization to organelle|
|molecular function|
|cellular amide metabolic process|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.76|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.43|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.2|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.2|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.11|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.07|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.02|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.92|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.85|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.81|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.8|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.8|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.77|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.76|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.76|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.7|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.93|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPCS1 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>