SPDL1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPDL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPDL1
  * **<color #00a2e8>Official Name</color>**: spindle apparatus coiled-coil protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54908|54908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EA4|Q96EA4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPDL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPDL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616401|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinetochore binding|
|condensed chromosome outer kinetochore|
|protein localization to kinetochore|
|protein localization to chromosome, centromeric region|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|establishment of mitotic spindle orientation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|negative regulation of mitotic nuclear division|
|establishment of spindle localization|
|mitotic metaphase plate congression|
|spindle localization|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|protein localization to chromosome|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|establishment of cell polarity|
|spindle pole|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|microtubule organizing center|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|establishment or maintenance of cell polarity|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|organelle fission|
|negative regulation of cell cycle process|
|enzyme binding|
|regulation of chromosome organization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|cell division|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.27|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.01|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.86|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.83|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.77|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.72|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.95|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 140/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|4/26|
|breast|6/33|
|central nervous system|12/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|7/21|
|liver|6/20|
|lung|14/75|
|lymphocyte|4/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2322
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPDL1 Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>