SPG11 [The Human Chemical-Genetic Interaction Map Project]

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======= SPG11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPG11
  * **<color #00a2e8>Official Name</color>**: SPG11 vesicle trafficking associated, spatacsin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80208|80208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JI7|Q96JI7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPG11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPG11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagosome-lysosome fusion involved in apoptotic cell clearance|
|phagosome maturation involved in apoptotic cell clearance|
|phagolysosome assembly involved in apoptotic cell clearance|
|phagosome-lysosome fusion|
|phagolysosome assembly|
|walking behavior|
|synaptic vesicle transport|
|axon extension|
|apoptotic cell clearance|
|synaptic vesicle localization|
|phagosome maturation|
|lytic vacuole organization|
|lysosome organization|
|neuron projection extension|
|axo-dendritic transport|
|vesicle fusion|
|organelle membrane fusion|
|developmental cell growth|
|cell growth|
|organelle fusion|
|developmental growth involved in morphogenesis|
|vacuole organization|
|membrane fusion|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|locomotory behavior|
|cytoplasmic vesicle|
|synapse|
|microtubule-based movement|
|axon|
|lysosomal membrane|
|vesicle organization|
|phagocytosis|
|establishment of organelle localization|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|behavior|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|organelle assembly|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|nucleolus|
|neuron differentiation|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.31|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.13|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5044
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPG11 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>