SPINK5 [The Human Chemical-Genetic Interaction Map Project]

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======= SPINK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPINK5
  * **<color #00a2e8>Official Name</color>**: serine peptidase inhibitor Kazal type 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11005|11005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ38|Q9NQ38]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPINK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPINK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kazal 2|
|Kazal 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of antimicrobial peptide production|
|negative regulation of antibacterial peptide production|
|negative regulation of antimicrobial humoral response|
|epidermal lamellar body|
|regulation of antimicrobial peptide production|
|regulation of antibacterial peptide production|
|regulation of timing of anagen|
|negative regulation of defense response to bacterium|
|regulation of antimicrobial humoral response|
|negative regulation of serine-type peptidase activity|
|negative regulation of serine-type endopeptidase activity|
|regulation of serine-type endopeptidase activity|
|regulation of hair follicle maturation|
|regulation of serine-type peptidase activity|
|negative regulation of humoral immune response|
|regulation of defense response to bacterium|
|regulation of hair follicle development|
|regulation of hair cycle|
|hair cell differentiation|
|negative regulation of production of molecular mediator of immune response|
|regulation of epidermis development|
|negative regulation of response to biotic stimulus|
|serine-type endopeptidase inhibitor activity|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|cornification|
|negative regulation of vasculature development|
|negative regulation of immune effector process|
|cell cortex|
|regulation of humoral immune response|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|negative regulation of immune response|
|regulation of lymphocyte differentiation|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|keratinization|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|regulation of leukocyte differentiation|
|keratinocyte differentiation|
|regulation of angiogenesis|
|epidermal cell differentiation|
|regulation of T cell activation|
|regulation of vasculature development|
|extracellular matrix organization|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|skin development|
|extracellular structure organization|
|epidermis development|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|central nervous system development|
|endoplasmic reticulum|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|regulation of response to stress|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|tissue development|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7550
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPINK5 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>