SPON1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPON1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPON1
  * **<color #00a2e8>Official Name</color>**: spondin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10418|10418]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCB6|Q9HCB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPON1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPON1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Reeler|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|LBD domain binding|
|negative regulation of amyloid-beta formation|
|negative regulation of amyloid precursor protein catabolic process|
|positive regulation of amyloid precursor protein catabolic process|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|regulation of amyloid-beta formation|
|regulation of amyloid precursor protein catabolic process|
|regulation of protein processing|
|regulation of protein maturation|
|positive regulation of protein binding|
|extracellular matrix structural constituent|
|negative regulation of cellular amide metabolic process|
|positive regulation of binding|
|regulation of protein binding|
|extracellular matrix|
|endoplasmic reticulum lumen|
|positive regulation of proteolysis|
|collagen-containing extracellular matrix|
|regulation of binding|
|regulation of cellular amide metabolic process|
|regulation of proteolysis|
|cell adhesion|
|biological adhesion|
|negative regulation of protein metabolic process|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16648
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPON1 Expression in NALM6 Cells: -1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>