SPRED1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPRED1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPRED1
  * **<color #00a2e8>Official Name</color>**: sprouty related EVH1 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=161742|161742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z699|Q7Z699]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPRED1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPRED1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609291|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WH1|
|Sprouty|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vasculogenesis involved in coronary vascular morphogenesis|
|stem cell factor receptor binding|
|protein serine/threonine kinase inhibitor activity|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of cell migration involved in sprouting angiogenesis|
|coronary vasculature morphogenesis|
|negative regulation of peptidyl-threonine phosphorylation|
|positive regulation of signal transduction by p53 class mediator|
|negative regulation of sprouting angiogenesis|
|inactivation of MAPK activity|
|negative regulation of blood vessel endothelial cell migration|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of cell migration involved in sprouting angiogenesis|
|regulation of protein deacetylation|
|regulation of peptidyl-threonine phosphorylation|
|coronary vasculature development|
|negative regulation of endothelial cell migration|
|phosphatase binding|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|vasculogenesis|
|regulation of sprouting angiogenesis|
|caveola|
|negative regulation of MAP kinase activity|
|fibroblast growth factor receptor signaling pathway|
|regulation of blood vessel endothelial cell migration|
|positive regulation of response to DNA damage stimulus|
|negative regulation of angiogenesis|
|negative regulation of phosphatase activity|
|negative regulation of blood vessel morphogenesis|
|cellular response to fibroblast growth factor stimulus|
|negative regulation of dephosphorylation|
|negative regulation of vasculature development|
|response to fibroblast growth factor|
|negative regulation of protein serine/threonine kinase activity|
|regulation of endothelial cell migration|
|negative regulation of MAPK cascade|
|regulation of phosphatase activity|
|regulation of signal transduction by p53 class mediator|
|regulation of dephosphorylation|
|regulation of response to DNA damage stimulus|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|cytoplasmic vesicle|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of MAP kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|protein kinase binding|
|blood vessel development|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|heart development|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|regulation of cell motility|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.73|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.81|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.81|
|[[:results:exp302|35°C R06 exp302]]|1.92|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.99|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPRED1 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>