SPRED2 [The Human Chemical-Genetic Interaction Map Project]

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======= SPRED2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPRED2
  * **<color #00a2e8>Official Name</color>**: sprouty related EVH1 domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=200734|200734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z698|Q7Z698]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPRED2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPRED2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609292|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. {ECO:0000269|PubMed:15683364}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sprouty|
|WH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stem cell factor receptor binding|
|protein serine/threonine kinase inhibitor activity|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of peptidyl-threonine phosphorylation|
|positive regulation of signal transduction by p53 class mediator|
|inactivation of MAPK activity|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|transport vesicle membrane|
|regulation of protein deacetylation|
|regulation of peptidyl-threonine phosphorylation|
|negative regulation of MAP kinase activity|
|fibroblast growth factor receptor signaling pathway|
|positive regulation of response to DNA damage stimulus|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of MAPK cascade|
|regulation of signal transduction by p53 class mediator|
|regulation of response to DNA damage stimulus|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|regulation of MAP kinase activity|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|protein kinase binding|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.73|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.78|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.94|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nf1|NF1]]|0.517|
|[[:human genes:d:dusp6|DUSP6]]|0.453|
|[[:human genes:z:zdhhc17|ZDHHC17]]|0.437|
|[[:human genes:r:rfwd2|RFWD2]]|0.425|
|[[:human genes:l:lztr1|LZTR1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7801
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPRED2 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>