SPRY1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPRY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPRY1
  * **<color #00a2e8>Official Name</color>**: sprouty RTK signaling antagonist 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10252|10252]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43609|O43609]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPRY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPRY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sprouty|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial to mesenchymal transition involved in cardiac fibroblast development|
|epicardium-derived cardiac fibroblast cell development|
|cardiac fibroblast cell differentiation|
|epicardium-derived cardiac fibroblast cell differentiation|
|cardiac fibroblast cell development|
|negative regulation of neurotrophin TRK receptor signaling pathway|
|bud elongation involved in lung branching|
|regulation of neurotrophin TRK receptor signaling pathway|
|organ induction|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|branch elongation of an epithelium|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|developmental induction|
|cardiac epithelial to mesenchymal transition|
|establishment of mitotic spindle orientation|
|regulation of fibroblast growth factor receptor signaling pathway|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|regulation of animal organ formation|
|establishment of spindle localization|
|lung morphogenesis|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of GTPase activity|
|spindle localization|
|negative regulation of ERBB signaling pathway|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|cardiac cell development|
|negative regulation of ERK1 and ERK2 cascade|
|epithelial to mesenchymal transition|
|negative regulation of MAP kinase activity|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|regulation of epidermal growth factor receptor signaling pathway|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|regulation of ERBB signaling pathway|
|mesonephros development|
|microtubule cytoskeleton organization involved in mitosis|
|developmental growth involved in morphogenesis|
|cardiocyte differentiation|
|establishment of cell polarity|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of cellular response to growth factor stimulus|
|mesenchymal cell differentiation|
|morphogenesis of a branching epithelium|
|negative regulation of MAPK cascade|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|mesenchyme development|
|negative regulation of protein kinase activity|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|renal system development|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|establishment of organelle localization|
|developmental growth|
|growth|
|negative regulation of protein phosphorylation|
|morphogenesis of an epithelium|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|heart development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|tube morphogenesis|
|microtubule-based process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|animal organ morphogenesis|
|regulation of transferase activity|
|Golgi apparatus|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8101
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPRY1 Expression in NALM6 Cells: 3.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>