SPTBN1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPTBN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTBN1
  * **<color #00a2e8>Official Name</color>**: spectrin beta, non-erythrocytic 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6711|6711]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01082|Q01082]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTBN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTBN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spectrin|
|CAMSAP CH|
|CH|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-2 secretion|
|common-partner SMAD protein phosphorylation|
|regulation of interleukin-2 secretion|
|spectrin|
|spectrin-associated cytoskeleton|
|cuticular plate|
|axolemma|
|ankyrin binding|
|regulation of SMAD protein signal transduction|
|M band|
|positive regulation of interleukin-2 production|
|actin filament capping|
|membrane assembly|
|GTPase binding|
|Golgi to plasma membrane protein transport|
|negative regulation of actin filament depolymerization|
|membrane biogenesis|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|establishment of protein localization to plasma membrane|
|regulation of interleukin-2 production|
|positive regulation of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|negative regulation of protein depolymerization|
|positive regulation of protein localization to cell periphery|
|negative regulation of protein polymerization|
|mitotic cytokinesis|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|vesicle-mediated transport to the plasma membrane|
|plasma membrane organization|
|regulation of protein localization to plasma membrane|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|post-Golgi vesicle-mediated transport|
|structural constituent of cytoskeleton|
|phospholipid binding|
|regulation of protein complex disassembly|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|positive regulation of cytokine secretion|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|protein localization to plasma membrane|
|regulation of actin filament length|
|regulation of protein localization to membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|calmodulin binding|
|regulation of cytokine secretion|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein polymerization|
|protein localization to cell periphery|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|postsynaptic density|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|establishment of protein localization to membrane|
|protein-containing complex binding|
|actin binding|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|cadherin binding|
|positive regulation of cellular protein localization|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|MAPK cascade|
|axonogenesis|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|positive regulation of secretion by cell|
|axon development|
|endomembrane system organization|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|regulation of peptide secretion|
|regulation of anatomical structure size|
|cell part morphogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|protein-containing complex|
|mitotic cell cycle process|
|neuron projection development|
|mitotic cell cycle|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|nucleolus|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|positive regulation of transport|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|RNA binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.04|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.98|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.95|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.89|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.8|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7358
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTBN1 Expression in NALM6 Cells: 11.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>