SPTSSA [The Human Chemical-Genetic Interaction Map Project]

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======= SPTSSA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTSSA
  * **<color #00a2e8>Official Name</color>**: serine palmitoyltransferase small subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=171546|171546]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969W0|Q969W0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTSSA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTSSA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA. {ECO:0000269|PubMed:19416851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3317|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine C-palmitoyltransferase activity|
|serine C-palmitoyltransferase complex|
|ceramide biosynthetic process|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|membrane lipid metabolic process|
|amide biosynthetic process|
|lipid biosynthetic process|
|cellular amide metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-3.03|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.77|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.41|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.23|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.07|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.06|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.86|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.85|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sptlc1|SPTLC1]]|0.561|
|[[:human genes:s:sptlc2|SPTLC2]]|0.55|
|[[:human genes:c:chka|CHKA]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 47/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|1/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|6/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7689
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTSSA Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>