SRD5A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SRD5A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRD5A1
  * **<color #00a2e8>Official Name</color>**: steroid 5 alpha-reductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6715|6715]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18405|P18405]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRD5A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRD5A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/184753|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Steroid dh|
|DUF1295|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|circadian sleep/wake cycle, REM sleep|
|amide binding|
|cholestenone 5-alpha-reductase activity|
|circadian sleep/wake cycle, sleep|
|3-oxo-5-alpha-steroid 4-dehydrogenase activity|
|circadian sleep/wake cycle process|
|androgen catabolic process|
|circadian sleep/wake cycle|
|cell body fiber|
|cellular response to testosterone stimulus|
|serotonin metabolic process|
|androgen biosynthetic process|
|response to fungicide|
|progesterone metabolic process|
|thalamus development|
|primary amino compound metabolic process|
|cellular response to epinephrine stimulus|
|sleep|
|NADPH binding|
|response to epinephrine|
|hormone catabolic process|
|response to follicle-stimulating hormone|
|female genitalia development|
|hypothalamus development|
|circadian behavior|
|male genitalia development|
|sex determination|
|rhythmic behavior|
|indole-containing compound metabolic process|
|response to muscle activity|
|androgen metabolic process|
|steroid catabolic process|
|response to gonadotropin|
|C21-steroid hormone metabolic process|
|cellular response to dexamethasone stimulus|
|myelin sheath|
|response to growth hormone|
|cellular response to estradiol stimulus|
|response to testosterone|
|response to dexamethasone|
|pituitary gland development|
|steroid hormone biosynthetic process|
|genitalia development|
|cellular response to cAMP|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|hormone biosynthetic process|
|response to activity|
|cellular ketone metabolic process|
|diencephalon development|
|response to estrogen|
|electron transfer activity|
|hippocampus development|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|cellular response to ketone|
|response to antineoplastic agent|
|response to cAMP|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|female sex differentiation|
|spinal cord development|
|diterpenoid metabolic process|
|limbic system development|
|cerebral cortex development|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|endocrine system development|
|liver development|
|steroid biosynthetic process|
|hepaticobiliary system development|
|male gonad development|
|development of primary male sexual characteristics|
|response to estradiol|
|response to organophosphorus|
|isoprenoid metabolic process|
|circadian rhythm|
|response to glucocorticoid|
|cellular response to starvation|
|response to purine-containing compound|
|male sex differentiation|
|response to corticosteroid|
|cellular response to insulin stimulus|
|pallium development|
|electron transport chain|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to starvation|
|ammonium ion metabolic process|
|response to ketone|
|bone development|
|hormone metabolic process|
|gonad development|
|development of primary sexual characteristics|
|response to insulin|
|cellular response to nutrient levels|
|telencephalon development|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|lipid catabolic process|
|response to xenobiotic stimulus|
|response to antibiotic|
|urogenital system development|
|cellular response to peptide|
|response to steroid hormone|
|cellular response to external stimulus|
|regulation of neurotransmitter levels|
|neuronal cell body|
|forebrain development|
|response to peptide hormone|
|cellular response to drug|
|gland development|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|organic hydroxy compound metabolic process|
|response to peptide|
|organic cyclic compound catabolic process|
|skeletal system development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|drug metabolic process|
|response to toxic substance|
|cellular response to lipid|
|response to extracellular stimulus|
|response to growth factor|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|behavior|
|lipid biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|perinuclear region of cytoplasm|
|brain development|
|head development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|central nervous system development|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.95|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.87|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.81|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRD5A1 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>