SREK1 [The Human Chemical-Genetic Interaction Map Project]

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======= SREK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SREK1
  * **<color #00a2e8>Official Name</color>**: splicing regulatory glutamic acid and lysine rich protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140890|140890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXA9|Q8WXA9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SREK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SREK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609268|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of alternative mRNA splicing, via spliceosome|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.59|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.56|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.54|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.4|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.25|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.22|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.21|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.11|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.1|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.08|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.06|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.04|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.98|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.97|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.97|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.97|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.87|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.82|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.77|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.77|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.73|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.76|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.78|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.79|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.83|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.83|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.12|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.14|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.17|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SREK1 Expression in NALM6 Cells: 8.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>