SRGAP2C [The Human Chemical-Genetic Interaction Map Project]

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======= SRGAP2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRGAP2C
  * **<color #00a2e8>Official Name</color>**: SLIT-ROBO Rho GTPase activating protein 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653464|653464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DJJ0|P0DJJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRGAP2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRGAP2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. {ECO:0000269|PubMed:22559944}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudopodium assembly|
|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|
|pseudopodium organization|
|negative regulation of filopodium assembly|
|modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration|
|cell motility involved in cerebral cortex radial glia guided migration|
|negative regulation of dendritic spine development|
|positive regulation of neuron migration|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|negative regulation of plasma membrane bounded cell projection assembly|
|negative regulation of dendrite development|
|cerebral cortex radially oriented cell migration|
|glial cell migration|
|regulation of neuron migration|
|cerebral cortex cell migration|
|regulation of filopodium assembly|
|Rac GTPase binding|
|telencephalon cell migration|
|forebrain cell migration|
|regulation of dendritic spine development|
|cerebral cortex development|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|pallium development|
|negative regulation of cell projection organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|gliogenesis|
|negative regulation of neuron differentiation|
|telencephalon development|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|forebrain development|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|regulation of neuron projection development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.46|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.09|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.78|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.71|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.72|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.77|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.89|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.98|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.02|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.11|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.14|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr87|WDR87]]|0.45|
|[[:human genes:d:dtl|DTL]]|0.449|
|[[:human genes:u:upf1|UPF1]]|0.447|
|[[:human genes:s:scaf1|SCAF1]]|0.438|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.431|
|[[:human genes:t:tceb3c|TCEB3C]]|0.429|
|[[:human genes:n:nup153|NUP153]]|0.417|
|[[:human genes:o:orc6|ORC6]]|0.415|
|[[:human genes:r:rps2|RPS2]]|0.409|
|[[:human genes:t:twistnb|TWISTNB]]|0.409|
|[[:human genes:n:npipb5|NPIPB5]]|0.408|
|[[:human genes:h:hivep3|HIVEP3]]|0.408|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.406|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.406|
|[[:human genes:a:ankle1|ANKLE1]]|0.405|
|[[:human genes:o:ogdh|OGDH]]|0.402|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1649
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRGAP2C Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>