SRRD [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SRRD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRRD
  * **<color #00a2e8>Official Name</color>**: SRR1 domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=402055|402055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UH36|Q9UH36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRRD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRRD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602254|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in a circadian clock input pathway. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of tetrapyrrole biosynthetic process|
|regulation of heme biosynthetic process|
|regulation of tetrapyrrole metabolic process|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|regulation of cofactor metabolic process|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|regulation of circadian rhythm|
|circadian rhythm|
|cofactor biosynthetic process|
|rhythmic process|
|cofactor metabolic process|
|microtubule-based process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.19|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.15|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.96|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.85|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.8|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.77|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.7|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.71|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.83|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.95|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.98|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.04|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.1|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.17|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.21|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.38|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.51|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.78|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.04|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.42|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot4|CNOT4]]|0.575|
|[[:human genes:d:dohh|DOHH]]|0.476|
|[[:human genes:b:bak1|BAK1]]|0.46|
|[[:human genes:s:serf2|SERF2]]|0.449|
|[[:human genes:c:casp9|CASP9]]|0.434|
|[[:human genes:m:march5|MARCH5]]|0.43|
|[[:human genes:k:kdsr|KDSR]]|0.43|
|[[:human genes:f:faf2|FAF2]]|0.425|
|[[:human genes:d:dpagt1|DPAGT1]]|0.422|
|[[:human genes:p:ppp6c|PPP6C]]|0.411|
|[[:human genes:t:thg1l|THG1L]]|0.41|
|[[:human genes:d:diablo|DIABLO]]|0.409|
|[[:human genes:a:apaf1|APAF1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRRD Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>