SRRT [The Human Chemical-Genetic Interaction Map Project]

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======= SRRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRRT
  * **<color #00a2e8>Official Name</color>**: serrate, RNA effector molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51593|51593]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXP5|Q9BXP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614469|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3546|
|ARS2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary miRNA processing|
|neuronal stem cell population maintenance|
|production of miRNAs involved in gene silencing by miRNA|
|response to arsenic-containing substance|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|gene silencing by RNA|
|ncRNA transcription|
|stem cell population maintenance|
|maintenance of cell number|
|gene silencing|
|regulation of gene expression, epigenetic|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|positive regulation of neurogenesis|
|ncRNA metabolic process|
|mRNA processing|
|transcription by RNA polymerase II|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of neurogenesis|
|RNA processing|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|RNA binding|
|DNA binding|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.71|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.75|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.77|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.88|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.92|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.06|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt5h|SUPT5H]]|0.435|
|[[:human genes:c:chd4|CHD4]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.425|
|[[:human genes:d:ddtl|DDTL]]|0.423|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.421|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.421|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.42|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.42|
|[[:human genes:m:med17|MED17]]|0.409|
|[[:human genes:c:cbwd3|CBWD3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 88/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|4/28|
|blood|7/28|
|bone|3/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|5/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 72
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRRT Expression in NALM6 Cells: 8.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>