SRSF10 [The Human Chemical-Genetic Interaction Map Project]

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======= SRSF10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF10
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10772|10772]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75494|O75494]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RS domain binding|
|mRNA 5-splice site recognition|
|spliceosomal tri-snRNP complex assembly|
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|spliceosomal snRNP assembly|
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|negative regulation of mRNA metabolic process|
|regulation of mRNA splicing, via spliceosome|
|unfolded protein binding|
|regulation of RNA splicing|
|regulation of mRNA processing|
|cytosolic transport|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|negative regulation of gene expression|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.45|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.19|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.97|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.96|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 209/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|8/28|
|bone|10/26|
|breast|8/33|
|central nervous system|24/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|7/21|
|liver|8/20|
|lung|14/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF10 Expression in NALM6 Cells: 9.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>