SRSF1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SRSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF1
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6426|6426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07955|Q07955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600812|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase binding|
|mRNA 5-splice site recognition|
|alternative mRNA splicing, via spliceosome|
|exon-exon junction complex|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|regulation of mRNA splicing, via spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|mRNA binding|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|intracellular protein transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.71|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.75|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.508|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:c:cdc73|CDC73]]|0.436|
|[[:human genes:p:ppie|PPIE]]|0.422|
|[[:human genes:i:iscu|ISCU]]|0.419|
|[[:human genes:p:psmb1|PSMB1]]|0.416|
|[[:human genes:p:psmb3|PSMB3]]|0.412|
|[[:human genes:r:rad21|RAD21]]|0.41|
|[[:human genes:n:nup85|NUP85]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.405|
|[[:human genes:d:dnm2|DNM2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 534/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|24/28|
|bone|17/25|
|breast|26/33|
|central nervous system|42/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|12/21|
|liver|14/20|
|lung|49/75|
|lymphocyte|13/14|
|ovary|18/26|
|pancreas|16/24|
|peripheral nervous system|10/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 29
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF1 Expression in NALM6 Cells: 9.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>