SSSCA1 [The Human Chemical-Genetic Interaction Map Project]

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======= SSSCA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNRD2
  * **<color #00a2e8>Official Name</color>**: zinc ribbon domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10534|10534]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60232|O60232]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSSCA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSSCA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Auto anti-p27|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division|
|mitotic cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.72|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.74|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.76|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.84|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.01|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.24|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdcd5|PDCD5]]|0.527|
|[[:human genes:h:hars|HARS]]|0.517|
|[[:human genes:v:vbp1|VBP1]]|0.479|
|[[:human genes:p:pfdn1|PFDN1]]|0.465|
|[[:human genes:t:tcp1|TCP1]]|0.451|
|[[:human genes:t:tbcd|TBCD]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11171
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSSCA1 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>