SST [The Human Chemical-Genetic Interaction Map Project]

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======= SST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SST
  * **<color #00a2e8>Official Name</color>**: somatostatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6750|6750]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61278|P61278]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Somatostatin inhibits the release of somatotropin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Somatostatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hormone-mediated apoptotic signaling pathway|
|response to acidic pH|
|hyperosmotic response|
|response to pH|
|response to osmotic stress|
|hormone activity|
|response to heat|
|digestion|
|response to amino acid|
|hormone-mediated signaling pathway|
|response to temperature stimulus|
|response to nutrient|
|apoptotic signaling pathway|
|response to steroid hormone|
|response to acid chemical|
|neuronal cell body|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|response to nutrient levels|
|response to extracellular stimulus|
|cellular response to hormone stimulus|
|negative regulation of cell population proliferation|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|apoptotic process|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SST Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>