STEAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= STEAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STEAP2
  * **<color #00a2e8>Official Name</color>**: STEAP2 metalloreductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=261729|261729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFT2|Q8NFT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STEAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STEAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605094|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferric reduct|
|F420 oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cupric reductase activity|
|iron ion import across cell outer membrane|
|ferric-chelate reductase (NADPH) activity|
|copper ion import|
|iron ion transmembrane transport|
|trans-Golgi network transport vesicle|
|copper ion transport|
|Golgi to plasma membrane transport|
|integral component of Golgi membrane|
|iron ion transport|
|iron ion homeostasis|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|transition metal ion transport|
|transition metal ion homeostasis|
|endosome membrane|
|early endosome|
|endosome|
|Golgi vesicle transport|
|endocytosis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|exocytosis|
|cation transport|
|response to hormone|
|ion transmembrane transport|
|oxidation-reduction process|
|secretion by cell|
|export from cell|
|chemical homeostasis|
|secretion|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|homeostatic process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.7|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.71|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9726
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STEAP2 Expression in NALM6 Cells: 2.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>