STEAP4 [The Human Chemical-Genetic Interaction Map Project]

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======= STEAP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STEAP4
  * **<color #00a2e8>Official Name</color>**: STEAP4 metalloreductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79689|79689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q687X5|Q687X5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STEAP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STEAP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). {ECO:0000250, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferric reduct|
|F420 oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron ion import across cell outer membrane|
|ferric-chelate reductase (NADPH) activity|
|cupric reductase activity|
|copper ion import|
|iron ion transmembrane transport|
|copper ion transport|
|protein homotrimerization|
|FAD binding|
|protein trimerization|
|iron ion transport|
|electron transfer activity|
|iron ion homeostasis|
|fat cell differentiation|
|transition metal ion transport|
|transition metal ion homeostasis|
|heme binding|
|early endosome membrane|
|electron transport chain|
|endosome|
|protein homooligomerization|
|generation of precursor metabolites and energy|
|protein complex oligomerization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|Golgi membrane|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|Golgi apparatus|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STEAP4 Expression in NALM6 Cells: 3.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>