STK39 [The Human Chemical-Genetic Interaction Map Project]

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======= STK39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STK39
  * **<color #00a2e8>Official Name</color>**: serine/threonine kinase 39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27347|27347]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UEW8|Q9UEW8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STK39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STK39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. {ECO:0000250|UniProtKB:Q9Z1W9}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OSR1 C|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of creatine transmembrane transporter activity|
|regulation of creatine transmembrane transporter activity|
|signal transduction by trans-phosphorylation|
|maintenance of lens transparency|
|chemokine (C-X-C motif) ligand 12 signaling pathway|
|negative regulation of pancreatic juice secretion|
|regulation of pancreatic juice secretion|
|cellular hypotonic response|
|hypotonic response|
|negative regulation of sodium ion transmembrane transporter activity|
|negative regulation of sodium ion transmembrane transport|
|negative regulation of anion transmembrane transport|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|negative regulation of sodium ion transport|
|negative regulation of digestive system process|
|negative regulation of potassium ion transmembrane transporter activity|
|negative regulation of organic acid transport|
|positive regulation of lymphocyte chemotaxis|
|negative regulation of potassium ion transmembrane transport|
|regulation of lymphocyte chemotaxis|
|regulation of anion transmembrane transport|
|negative regulation of response to drug|
|negative regulation of anion transport|
|positive regulation of T cell migration|
|negative regulation of potassium ion transport|
|cellular response to osmotic stress|
|positive regulation of lymphocyte migration|
|regulation of digestive system process|
|regulation of T cell migration|
|positive regulation of potassium ion transport|
|regulation of sodium ion transmembrane transporter activity|
|regulation of potassium ion transmembrane transporter activity|
|regulation of organic acid transport|
|regulation of lymphocyte migration|
|regulation of sodium ion transmembrane transport|
|extrinsic component of membrane|
|negative regulation of ion transmembrane transporter activity|
|response to osmotic stress|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|kinase activity|
|chemokine-mediated signaling pathway|
|peptidyl-threonine phosphorylation|
|negative regulation of cation transmembrane transport|
|regulation of sodium ion transport|
|positive regulation of leukocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|peptidyl-threonine modification|
|negative regulation of ion transmembrane transport|
|regulation of anion transport|
|regulation of potassium ion transport|
|regulation of response to drug|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|regulation of leukocyte chemotaxis|
|negative regulation of transmembrane transport|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|stress-activated protein kinase signaling cascade|
|negative regulation of ion transport|
|positive regulation of ion transmembrane transport|
|activation of MAPK activity|
|peptidyl-serine phosphorylation|
|regulation of blood pressure|
|tissue homeostasis|
|protein autophosphorylation|
|regulation of leukocyte migration|
|basolateral plasma membrane|
|peptidyl-serine modification|
|positive regulation of transmembrane transport|
|regulation of chemotaxis|
|negative regulation of secretion|
|regulation of ion transmembrane transporter activity|
|positive regulation of MAP kinase activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|apical plasma membrane|
|multicellular organismal homeostasis|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|protein serine/threonine kinase activity|
|cytoskeleton|
|regulation of metal ion transport|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|protein kinase binding|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|positive regulation of response to external stimulus|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|regulation of MAPK cascade|
|regulation of defense response|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.92|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.91|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.74|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.91|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.95|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.51|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9922
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STK39 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>