STMN2 [The Human Chemical-Genetic Interaction Map Project]

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======= STMN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STMN2
  * **<color #00a2e8>Official Name</color>**: stathmin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11075|11075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93045|Q93045]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STMN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STMN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Stathmin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule depolymerization|
|negative regulation of microtubule polymerization|
|microtubule depolymerization|
|positive regulation of protein depolymerization|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|positive regulation of microtubule polymerization or depolymerization|
|protein depolymerization|
|positive regulation of protein complex disassembly|
|negative regulation of microtubule polymerization or depolymerization|
|cellular response to nerve growth factor stimulus|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|response to nerve growth factor|
|tubulin binding|
|negative regulation of protein depolymerization|
|calcium-dependent protein binding|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|growth cone|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|cellular protein complex disassembly|
|negative regulation of cytoskeleton organization|
|negative regulation of neuron projection development|
|lamellipodium|
|negative regulation of cell projection organization|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|protein-containing complex disassembly|
|endosome|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|neuron projection|
|negative regulation of cell development|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|cellular component disassembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|response to growth factor|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|Golgi apparatus|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STMN2 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>